Job offers:

The lab is seeking motivated honours, graduate students, and post-doctoral fellows. You can apply via email with an attached cover letter, transcripts and detailed curriculum vitae.

NEW OFFER: Jan 2026

Characterization of Extracellular Vesicle (EV) Dysfunction in Myotonic Dystrophy Type 1 (DM1)

The Ravel-Chapuis Laboratory is seeking a highly motivated MSc or PhD student to join an active research program focused on the molecular and cellular pathomechanisms of neuromuscular disorders.

Project description

Myotonic Dystrophy type 1 (DM1) is a neuromuscular and multisystemic disorder caused by a genetic mutation that disrupts normal cellular function, leading to the wide range of clinical manifestations characteristic of the disease. Over the past several years, our laboratory has identified a dysfunction in extracellular vesicle (EV) production in DM1 skeletal muscle. This project aims to build on these findings by elucidating the molecular mechanisms underlying EV dysregulation in DM1 and determining the functional consequences of this dysfunction on muscle and systemic pathology.

Methodologies

The project will involve a combination of molecular and cellular biology approaches, including: Cell culture, Western blotting, RT-PCR and quantitative PCR (qPCR), Immunofluorescence microscopy.

Candidate profile

Applicants should have a strong interest in neuromuscular biology and disease mechanisms. Prior experience in molecular and/or cellular biology techniques is an asset but not required, as training will be provided.

How to apply

Interested candidates are invited to submit a curriculum vitae and a brief cover letter to Aymeric.Ravel-Chapuis@uottawa.ca . Applications may be submitted in either French or English.